Endocrine Abstracts

Introduction: Thyroid cancer (TC) in adolescents and adults (AYA) is defined as thyroid cancer diagnosed among those aged between 15-39 years. It is the fifth most common cancer in AYAs, and its incidence is increasing. Compared with older adult patients, the AYA with TC has a higher prevalence of node metastasis which represents a risk factor for recurrence.Aim: To describe the characteristics of thyroid carcinoma with confirmed nodal metastases at the ...

Thyroid cancer is the most common malignancy of endocrine organs and its incidence is steadily growing worldwide. Approximately 80% of differentiated thyroid tumors are papillary carcinomas. Next-generation sequencing (NGS) allows for high-throughput sequencing analysis of large number of samples at a time in a cost effective manner. We have developed a targeted sequencing parallel testing panel for multiple mutations in genes involved in thyroid cancer pathology. A custom-mad...

Androgen receptor (AR) containes a variable polyglutamine chain that is determined by the different number of CAG repeats in the AR gene on the X chromosome. The transactivational competence of AR is inversely related to the length of the polyglutamine chain, respectively to the CAG repeat number. Therefore, we investigated the role of the androgen receptor polymorphism in healthy hirsute and non hirsute women.CAG repeat length polymorphism was analyzed ...

A 45-year-old lady presented to her GP with sweating, poor memory, and decreased, concentration. Investigations revealed elevated oestradiol at 2204 pmol/l, LH at 28.1 IU/l, and FSH at 15.0 IU/l. This raised the possibility of a Gonadotrophinoma. A preclinic pituitary MRI showed a subtle rounded nodule of tissue within the right side of the anterior pituitary. In clinic, she revealed that she was consuming aloe vera juice for several years to improve her skin and general well-...

Aim: Healthy adipose tissue contains numerous innate and adaptive immune cells that carry a type 2 cytokine immune signature, controlled by IL-33 and reflected by accumulation of ST2+ T regulatory cells (Tregs), type 2 innate lymphoid cells (ILC2s), and alternatively activated macrophages. These type 2 responses are lost in mice or humans on high-caloric diets that lead to obesity. Understanding how type 2 immunity is regulated in adipose tissue could contribute to ...

Introduction: A Patient Held Record (PHR) has been developed for use in adolescent girls with Turner Syndrome (TS) attending a dedicated Turner Transition clinic, RHC Glasgow. The PHR has been devised to encourage knowledge of TS; medcial care and ways to maintain good health and to promote self advocacy.Aim: To assess patient acceptability and user friendliness of a PHR in adolescent girls with TS.Method: A PHR and questionnaire w...

Familial non-medullary thyroid cancer (FNMTC) constitutes about 3–9% of all thyroid cancers. One of the genes believed to predispose to non-syndromic FNMTC is FOXE1. It contains a polyalanine tract (polyAla) with a variable number (11 – 22) of alanine residues. This length polymorphism could lead to changes in the FOXE1-encoded protein (FOXE1 transcription factor) structure and predispose to papillary thyroid cancer (PTC). The aim of the st...

Introduction: Selenium supplementation is recommended for all patients with mild Graves’ orbitopathy (GO). The thyroid gland contains high levels of selenium, which has an anti-oxidant effect and a role in the metabolism of thyroid hormones. The study on which this recommendation is based was conducted in countries of a selenium-deficient region and did not measure subjects’ selenium concentrations. There is therefore no consensus on optimum dose, duration, or safety...

A 60 year old lady presented to her GP with symptoms, she described as ‘morning sickness’.She also reported nausea (better after eating), mild epigastric discomfort.Examination revealed a soft non tender abdomen, with no organomegaly.She was referred for urgent upper GI endoscopy and abdominal USS.Initial bloods showed impaired liver function,...

A 60 year old lady presented to her GP with symptoms, she described as ‘morning sickness’.She also reported nausea (better after eating), mild epigastric discomfort.Examination revealed a soft non tender abdomen, with no organomegaly.She was referred for urgent upper GI endoscopy and abdominal USS.Initial bloods showed impaired liver function,...